MODELING HUMAN DISEASES IN C. elegans

 

Financial support: 

FIS - Instituto de Salud Carlos III

Marató TV3

Fundación ONCE

RNA processing AND DISEASE

Mechanisms of RNA processing are highly conserved from yeast to humans and necessary to transfer DNA information to protein synthesis.

Therefore, this process is essential for gene expression programs and is frequently altered in human diseases. While most of the information about RNA processing comes  from biochemical and in vitro studies, we use the multicellular organism C. elegans because of its powerful genetic and genomic tools to shed light on steps of RNA metabolism that are impaired in diverse diseases.

 

cancer

Most of the mechanisms that contribute to the onset and development of cancer are conserved along evolution. In C. elegans we study why disruption of gene functions can contribute to genome instability, cell death or uncontrolled cell divisions.

Interestingly, many of the chemotherapies and radiotherapies applied to humans also produce an effect in worms. We are studying mechanisms that confer sensitivity and resistance to these therapies against cancer.

 

ACTIVE COLLABORATIONS::


Alberto Villanueva, ICO/IDIBELL, Barcelona, SPAIN

Lluis Espinosa, PRBB, Barcelona, SPAIN

Sebastian Honnen, Dusseldorf, GERMANY

Carina Holmberg-Stil, Helsinki, FINLAND

Alan Zahler, UCSC, Santa Cruz, USA

Ernest Nadal, ICO, Barcelona, Spain

Denis Dupuy, Bourdeaux, France

M. A. Pujana, ICO/IDIBELL, Barcelona, Spain